Von der Leyen's comments come as US officials will host the Danish and Greenlandic foreign ministers at the White House for crunch talks later on Wednesday,
Euronews reports.
European Commission President Ursula von der Leyen expressed support for Greenland on Wednesday, saying the Arctic island which US President Donald Trump has vowed to seize "belongs to its people".
"For me it's important that the Greenlanders know and they know this by the deeds, not only by the words, that we respect the wishes of the Greenlanders and their interests and that they can count on us," she said at a press conference in Brussels.
Her comments come as US Vice President JD Vance and Secretary of State Marco Rubio will host the Danish and Greenlandic foreign ministers at the White House later on Wednesday.
Denmark's Foreign Minister Lars Lokke Rasmussen told reporters that he and his Greenlandic counterpart, Vivian Motzfeldt, had requested a meeting with US President Donald Trump after he escalated his threats to annex the self-governing Danish territory.
"Our reason for seeking the meeting we have now been given was to move this whole discussion ... into a meeting room where we can look each other in the eye and talk about these things," Rasmussen said in Copenhagen on Tuesday.