Sir Keir Starmer and Donald Trump discussed "ongoing and productive" trade talks, No 10 has said, in their first call since the US president imposed tariffs on UK goods,
BBC reports.
The prime minister stressed his commitment to "free and open trade and the importance of protecting the national interest", a Downing Street spokesperson said.
They added that the two leaders also discussed "the situation in Ukraine, Iran and recent action taken against the Houthis in Yemen".
Sir Keir is hoping to secure a deal with the US after Trump unveiled 10% tariffs on UK goods and a higher 25% rate on imports of cars, steel and aluminium.
"The leaders began by discussing the ongoing and productive discussions between the UK and US on trade," No 10 said in a statement.
A readout of the call from the White House said the two leaders discussed bilateral trade, ongoing talks to bring the conflict in Ukraine to a peaceful resolution, and regional security in the Middle East.
It added that Trump was looking forward to his upcoming state visit with His Majesty King Charles III in the UK later this year.
US Vice-President JD Vance said on Tuesday there was a "good chance" a trade deal could be reached with the UK.
Trump announced a barrage of tariffs earlier this month and shares on stock markets around the world have since tumbled.
The S&P 500 index of the largest firms listed in the US, the UK FTSE 100, German Dax, and French Cac 40 have recovered some value as Trump has delayed some tariffs and made exceptions, but are lower than before 2 April.
The current tariff policy now puts a 10% "baseline" tariff on all imports from the UK, France and other long-standing trade partners. China faces much harsher tariffs.
A tariff is a tax on businesses buying a good from overseas, but businesses often pass the costs from the tariff onto the consumer or overseas the seller.
